Leukotriene A4

(2S-(2 alpha,3 beta(1E,3E,5Z,8Z)))-3-(1,3,5,8-Tetradecatetraenyl)oxiranebutanoic acid. An unstable allylic epoxide, formed from the immediate precursor 5-HPETE via the stereospecific removal of a proton at C-10 and dehydration. Its biological actions are determined primarily by its metabolites, i.e., LEUKOTRIENE B4 and cysteinyl-leukotrienes. Alternatively, leukotriene A4 is converted into LEUKOTRIENE C4 by glutathione-S-transferase or into 5,6-di-HETE by the epoxide-hydrolase. (From Dictionary of Prostaglandins and Related Compounds, 1990)

Also Known As:

Leukotriene A; Leukotriene A-4; Leukotrienes A; Leukotriene A 4; LTA4

Lipids: 114793
- Fatty Acids: 27405
  - Unsaturated Fatty Acids: 8236
    - Eicosanoids: 3262
      - Arachidonic Acids: 122
        Leukotrienes: 4095
        Leukotriene A4: 73
    - Essential Fatty Acids: 734
      - Arachidonic Acids: 122
        Leukotrienes: 4095
        Leukotriene A4: 73
Biological Factors: 2472
- Inflammation Mediators: 1113
  - Autacoids: 276
    - Eicosanoids: 3262
      - Leukotrienes: 4095
        Leukotriene A4: 73

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R Chapela Research Topics

Disease

Drug/Important Bio-Agent (IBA)